Circulating cell-free transcriptomics in cancer

Transcriptomics (or functional genomics) is a powerful tool that allow researchers to connect their knowledge of cells, biomarkers, and disease onset, hence providing novel diagnostic therapeutic solutions perspectives. It includes the tempo-spatial distribution, communication interaction key cellular mRNA biomarkers cross-talking networks, role in influencing intracellular extracellular dynamics signaling. Circulating cell-free transcriptomics uses data from plasma transcriptomes, or whole circulating (cfmRNA) content, determine roles functions for biomarker discovery. This short highlights some technologies powering advances field, including current trends innovations, future challenges possibilities—some which were unthinkable few years ago.